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These demonstrate that CTF is a potent oncogene capable of promoting mammary tumor progression and metastasis. It is thought that transgenic mice overexpressing HER2 in the mammary glands develop tumors only after acquisition of escort incall mutations in the transgene.

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In contrast, we show that expression of CTF led to development of aggressive and invasive mammary tumors without the need for mutations.

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Full description or abstract HER2 is a 6889 kinase urban dictionary pse causally involved in cancer. A transcriptomic analysis revealed that CTF specifically controlled the expression of genes that we found to be correlated with poor prognosis in breast cancer.

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